Luis R. Saraiva, PhD

Director – Metabolism and Diabetes Program Principal Investigator – Associate Level Laboratory of Neurogenetics, Behavior and Disease

Email: lsaraiva (@) sidra.org

Selected Publications (equal contribution, *corresponding):

  • Saraiva, LR*; Aguilera, FRM; Mezzavilla,M; Abou-Moussa, EH; Arayata, CJ; Makhlouf, M; Trimmer, C; Ibarra-Soria, X; Khan, M; van Gerven, L; Jorissen, M; Gibbs, M; O'Flynn, C; McGrane, S; Mombaerts, P; Marioni, JR; Mainland, JD; Logan, DW*. “A transcriptomic atlas of mammalian olfactory mucosae reveals an evolutionary influence on food odor detection in humans”. Sci Adv(2019) 5(7):eaax0396.
  • Manoel, D; Makhlouf, M; Scialdone, A;Saraiva, LR*. “Interspecific variation of olfactory preferences in flies, mice, and humans”. Chem Senses(2019) 44(1):7-9.
  • Ibarra-Soria, X; Nakahara, TS; Lilue, J; Jiang, Y; Trimmer, C; Souza, MAA; Netto, PHM; Ikegame, K; Murphy NR; Kusma, M; Kirton, A; Saraiva, LR; Keane, TK; Matsunami, H; Mainland, JD; Papes, F; Logan, DW.“Variation in olfactory neuron repertoires is genetically controlled and environmentally modulated”. eLife (2017) 6:e21476.
  • Ambrosi, TH; Scialdone, A; Graja, A; Gohlke, S; Jank, A-M; Woelk, L; Fan, H; Logan, DW; Schürmann, A;Saraiva, LR; Schulz, TJ. “Adipocyte accumulation in the bone marrow during obesity and aging impairs stem cell-based hematopoietic and bone regeneration”. Cell Stem Cell (2017) 20: 1–14.
  • Lam, BYH; Cimino, I; Polex-Wolf, J; Kohnke, SN; Rimmington, D; Iyemere, V; Heeley, N; Cossetti, C; Schulte, R; Saraiva, LR; Logan, DW; Blouet, C; O’Rahilly, S; Coll, AP; Yeo, GSH.“Heterogeneity of hypothalamic Pro-opiomelanocortin-expressing neurons revealed by single-cell RNA sequencing”. Mol Metab (2017) 1-10.
  • Saraiva, LR; Kondoh, K; Ye,X; Yoon, K-h; Hernandez, M; Buck LB.Combinatorial effects of odorants on mouse behavior”. Proc Natl Acad Sci USA (2016) 113(23):E3300-6.
  • Saraiva, LR; Ibarra-Soria, X; Khan, M; Omura, M; Scialdone, A; Mombaerts, P; Marioni, JC; Logan, DW. “Hierarchical deconstruction of mouse olfactory sensory neurons: from whole mucosa to single-cell RNA-seq”. Sci Rep (2015) 5:18178.
  • Saraiva, LR; Ahuja, G; Syied, A; Ivandicic, I; Marioni, JC; Korsching, SI; Logan, DW. “Molecular and neuronal homology between the olfactory systems of zebrafish and mouse”. Sci Rep (2015) 5: 11487.
  • Achim, K; Pettit, JB; Saraiva, LR; Gavriouchkina, D; Arendt, D; Marioni, JC. “High-throughput spatial mapping of single-cell RNA-seq data to tissue of origin”. Nat Biotechnol (2015) 33(5): 503-9.
  • Hussain, A ; Saraiva, LR; Ferrero, SD ; Ahuja, G ; Krishna, VS; Liberles, SD; Korsching SI. “High affinity olfactory receptor for the death-associated odor cadaverine”. Proc Natl Acad Sci USA (2013) 110(48): 19579-84.