Advanced Imaging Core (AIC)

We provide expert consultation to support experimental design, imaging strategy selection, and technology optimization. Working closely with investigators, our team helps align research objectives with appropriate imaging modalities to ensure robust, reproducible, and meaningful results.

The Advanced Imaging Core offers both assisted and unassisted imaging options to accommodate diverse project needs and user experience levels. Assisted imaging provides hands-on expert support for complex experiments, while trained users may access unassisted imaging for independent data acquisition.

We support high-throughput imaging-based screening and drug testing workflows to enable quantitative assessment of biological responses across large sample sets. Using automated widefield and high-content imaging systems (CD7, BC43), we support multiwell plate–based assays, drug screening, and large-scale phenotypic studies. Standardized acquisition protocols ensure consistency and reproducibility across high-throughput experiments.

The Advanced Imaging Core supports complex imaging workflows for sophisticated biological questions, including automated, multiplexed, and large-scale imaging applications. These approaches enable detailed interrogation of cellular and tissue-level phenotypes across diverse research models.

We provide comprehensive image analysis and quantification workflows using tools such as ZEN Blue, Imaris, HALO, Fiji/ImageJ, and CellProfiler. Services include deconvolution, 3D/4D visualization, segmentation, cell phenotyping, spatial mapping, and quantitative measurements from single cells to whole tissues.

The Advanced Imaging Core supports a centralized image repository using the Concentriq platform for H&E and immunofluorescence images. This enables secure, role-based access to whole-slide and multiplex datasets, remote viewing and annotation, teaching collections, and the development of AI-ready image datasets for research and clinical innovation.

We provide structured training and certification on core imaging instruments, alongside regular workshops and courses covering optical microscopy, image analysis, and application-focused topics such as zebrafish imaging, multiplex immunofluorescence, and spatial workflows.

The Advanced Imaging Core supports specialized and clinical-adjacent workflows, including ovarian tissue viability validation for the IVF clinic, zebrafish imaging and analysis for the Pathology Department, and multiplex tissue imaging for translational oncology projects.