The Immune Dysregulation Program

Immune dysregulation poses a significant clinical challenge, manifesting in diverse conditions like allergies, autoimmunity, inflammation, and cancer. These patients often present with unusual symptoms, complicating diagnosis and treatment. Treatment resistance or lack of established protocols further exacerbate the issue. Immune dysregulation disorders range from common, multifactorial conditions to rare monogenic disorders, which are notably prevalent in Qatar and the MENA region. Studying rare monogenic disorders, despite their individual rarity, offers valuable insights into pathogenic mechanisms and potential therapeutic targets applicable to more common polygenic immune dysregulation disorders. The planned Gold Cohorts for this program include:

• Monogenic disorders of immune dysregulation
• Inflammatory bowel disorders