Sidra ACTC is an integrated core facility that hosts a Stem Cell Program for cell, gene therapy and regenerative medicine entailing facilities, clinical grade equipment, laboratories for Research & Development, clean rooms and laboratories for Good Manufacturing Practice (GMP) to scale up to clinical production. Clean rooms and GMPs are based on non-conventional high-tech modular systems unique in the Gulf and can dynamically adapt to new future requirements. Activities currently range from Hematopoietic Stem Cells processing, as part of the Bone Marrow Transplantation clinical program, to several projects of cell therapy (i.e. production of mesenchymal stromal cell from different sources), gene therapy (i.e. anti-tumor engineered Chimeric Antigen Receptor T-cells) and regenerative medicine (i.e. production of platelet rich plasma, platelet rich fibrin, adipose-derived stem cells and cell-drug codelivery). ACTC aims to follow international standards and guidelines (ISO9001, GMP, JACIE-FACT) for the safe delivery of ACTs to patients.Research interests on:• Mesenchymal Stromal Cells (deep phenotyping, secretome, lipidomics and metabolomics, etc);• Anti-tumor engineered Chimeric Antigen Receptor T-cells;• Pediatric leukemia (phosphoFlow cytometry, epigenetics and pharmacogenomics);• Inherited Bone Marrow Failure Syndromes (genetic and epigenetic make-up);• Graft-versus-host disease.
Sara Deola, MD, PhDPrincipal InvestigatorEmail: sdeola (@) sidra.orgCristina Maccalli, PhDPrincipal InvestigatorEmail: cmaccalli (@) sidra.orgMassimino Miele, BScLab ManagerEmail: mmiele (@) sidra.orgRita Calzone, MScResearch SpecialistEmail: rcalzone (@) sidra.orgChe-Ann Lachica, BScResearch SpecialistEmail: clachica (@) sidra.orgSheanna Marie Herrera, MScResearch SpecialistEmail: sherrera (@) sidra.orgAsma Al-Sulaiti, BScResearch SpecialistEmail: aalsuilaiti1 (@) sidra.orgMoza Al- Khulaifi, BScResearch SpecialistEmail: malkhulaifi (@) sidra.orgHeba Sidahmed, MBBs,MRCsPost-Doctoral fellowEmail: hsidahmed (@) sidra.orgGiusy Gentilcore, PhDResearch SpecialistEmail: ggentilcore (@) sidra.orgBella Guerrouahen, PhDPost-Doctoral Fellow (grant-funded position)Email: bguerrouahen (@) sidra.orgSaad Rasool, BScResearch Specialist (grant-funded position)Email: srasool(@) sidra.orgShilpa Ravindran, MScResearch Specialist (grant-funded position)Email: sravindran(@) sidra.orgMuhammad Elnaggar, MDPost-Doctoral FellowEmail: melnaggar (@) sidra.orgDhanya Kizhakayil, PhDResearch SpecialistEmail: dkizhakayil (@) sidra.orgAnjud Al-Mohannadi, MScResearch SpecialistEmail: aalmohannadi2 (@) sidra.org
Advanced Cell Therapy Core — A.C.T.C.
Chiara Cugno, MD
Director – Advanced Cell Therapy Core (ACTC)
Attending Physician – Pediatric Oncology and Hematology
Biography and Contact Details