Precision Medicine and Functional Genomics 2022
Biotech Forum
22 September 2022
Sidra Medicine, Hospital Auditorium
23-26 September 2022
St. Regis, Doha
| Day 1: Friday 23rd September 2022 | |||
| Topic: Worldwide National Programs and Clinical Trials of Precision Medicine | |||
| Session 1: How can personalized approaches pave the way to Next-Generation Medicine?
Session Chairs: Dr. Khalid Fakhro and Dr. David Brown |
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| Objectives:
· Learn about coordinated efforts on developing Precision Medicine around the world · Understand how these efforts bring the promise of changing medicine · Learn how advanced diagnostics and personalized treatments improve the quality of patient care |
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| 13:00 | 13:35 | Opening Keynote lecture: Dr. Dan Roden
Vanderbilt University, USA |
Electronic Health Records as key tools in discovery and implementation in Precision Medicine |
| 13:35 | 14:00 | Dr. Astrid Vicente
National Institute of Health Doutor Ricardo Jorge (INSA), ICPerMed, Portugal |
The ICPerMed vision for Personalized Medicine in 2030 – making progress towards implementation |
| 14:00 | 14:25 | Dr. Dave Brown
QPMI, Qatar |
Shift to targeted treatment and how it will change the life sciences industry response to clinical demand |
| 14:25 | 14:50 | Dr. Patrick Tan
Precision Health Research (PRECISE) Singapore |
Transforming Health in Singapore through Precision Medicine |
| 14:50 | 15:15 | Dr. Maryam Mohd Fatma Matar
UAE Genetic Diseases Association (UAEGDA) |
Upgrading our disease care system to Health care system. Precision Health (precision medicine) |
| 15:15 | 15:45 | Break | |
| 15:45 | 16:20 | Keynote Speaker: Dr. Yibin Kang Princeton University, USA | Targeting cancer fitness genes in metastatic cancers |
| Session 2: Precision Medicine Trials: barriers and best practices
Session Chairs: Dr. Antonella Cioce and Dr. Ata Maaz |
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| Objectives:
· Learn about best practices for conducting successful Precision Medicine Trials. · Understand how cancer treatment is benefiting from Precision Medicine approaches. · Discover the need of networking for improving Precision Medicine in rare disorders (i.e., pediatric cancer). · Learn about current barriers for clinical trials and explore ways to overcome them. |
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| 16:20 | 16:45 | Dr. Alice Chen
National Cancer Institute, US |
The Precision Medicine Initiatives of the NCI |
| 16:45 | 17:10 | Dr. Mirjam Blatter-Johnson
Hopp Children’s Cancer Center, Germany |
More trials or more precision? Clinical outcome and benefit of the European wide pediatric precision oncology study INFORM |
| 17:10 | 17:35 | Dr. Shaikha Saif Al Mazrouei
UAE |
Hepatocyte Microbeads Transplantation |
| 17:35 | 18:00 | Dr. Michaela Semeraro (Online)
Necker Children’s Hospital, France |
Building pediatric rare disease clinical trials with innovative treatments |
| 18:00 | 18:10 | Closing | |
Day 1: Friday 23 September 2022
Worldwide National Programs and Clinical Trials of Precision Medicine
| Session 1: How can personalized approaches pave the way to Next-Generation Medicine? Session Chairs: Dr. Khalid Fakhro and Dr. David Brown |
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| Objectives: · Learn about coordinated efforts on developing Precision Medicine around the world · Understand how these efforts bring the promise of changing medicine · Learn how advanced diagnostics and personalized treatments improve the quality of patient care |
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| 13:00 | 13:35 | Opening Keynote lecture: Dr. Dan Roden Vanderbilt University, USA |
Electronic Health Records as key tools in discovery and implementation in Precision Medicine |
| 13:35 | 14:00 | Dr. Astrid Vicente
National Institute of Health Doutor Ricardo Jorge (INSA), ICPerMed, Portugal |
The ICPerMed vision for Personalized Medicine in 2030 – making progress towards implementation |
| 14:00 | 14:25 | Dr. Dave Brown
QPMI, Qatar
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Shift to targeted treatment and how it will change the life sciences industry response to clinical demand |
| 14:25 | 14:50 | Dr. Patrick Tan
Precision Health Research (PRECISE), Singapore |
Transforming Health in Singapore through Precision Medicine |
| 14:50 | 15:15 | Dr. Imed Gallouzi
KAUST, Saudi Arabia |
KAUST Smart Health Initiative: concrete steps towards precision medicine |
| 15:15 | 15:45 | Break | |
| 15:45 | 16:20 | Keynote Speaker: Dr. Yibin Kang Princeton University, USA
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Targeting cancer fitness genes in metastatic cancers
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| Session 2: Precision Medicine Trials: barriers and best practices
Session Chairs: Dr. Antonella Cioce and Dr. Ata Maaz |
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| Objectives:
· Learn about best practices for conducting successful Precision Medicine Trials. · Understand how cancer treatment is benefiting from Precision Medicine approaches. · Discover the need of networking for improving Precision Medicine in rare disorders (i.e., pediatric cancer). · Learn about current barriers for clinical trials and explore ways to overcome them.
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| 16:20 | 16:45 | Dr. Alice Chen
National Cancer Institute, USA |
The Precision Medicine Initiatives of the NCI |
| 16:45 | 17:10 | Dr. Mirjam Blatter-Johnson
Hopp Children’s Cancer Center, Germany |
More trials or more precision? Clinical outcome and benefit of the European wide pediatric precision oncology study INFORM |
| 17:10 | 17:35 | Dr. Shaikha Saif Al Mazrouei | Hepatocyte Microbeads Transplantation |
| 17:35 | 18:00 | Dr. Michaela Semeraro (Recorded or online)
Necker Children’s Hospital, France |
Building pediatric rare disease clinical trials with innovative treatments
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| 18:00 | 18:10 | Closing
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| Day 2: Saturday 24th September 2022
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| Topic- Technologies and clinical approaches advancing Precision Medicine and pediatric cancer immunotherapy. | |||
| 8:00 | 8:30 | Opening Note | |
| Session 1: Precision Medicine Technology platforms
Session Chairs: Dr. Julie Decock and Dr. Rayaz Malik |
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| Objectives:
· Understand the value of Precision Drug Screening. · Learn about modeling of human tissues and diseases. · Learn about technology platforms for advanced genomics, proteomics, imaging and flow cytometry available in Qatar.
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8:30
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8:55 | Dr. Yu Shrike Zhang
Harvard Stem Cell Institute, USA |
High-content modeling of human tissues and diseases in vitro for Precision Drug Screening |
| 8:55 | 9:30 | Opening Keynote: Dr. Gorka Orive
University of the Basque Country, Spain
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Progress in the field of cell-laden hydrogels
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| 9:30 | 9:45 | Dr. Shana Jacob & Dr. Abbirami Sathappan & Dr. Giusy Gentilcore
Sidra Medicine, Qatar |
Precise cellular and molecular phenotyping: routine and bespoke services in Sidra |
| 9:45 | 10:00 | Dr. Stephan Lorenz
Sidra Medicine, Qatar |
Integrated Genomics Services – a platform for Precision Medicine and genomic discoveries |
| 10:00 | 10:15 | Dr. Houari B. Abdesselem
Jilbin Sam Plammoottil George Qatar Biomedical Research Institute, Qatar |
Defining Key Platforms in QBRI Core Lab Facilities: Sengenics Autoantibody Profiling, Olink Proteomics, and Cytometry Technologies
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| 10:15 | 10:30 | Dr. Frank Schmidt
Weil Cornell Medical College, Qatar |
Advanced multiplex proteomics techniques in clinical proteomics: an ideal tool for biomarker discovery
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| 10:30 | 11:00 | Break
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| Session 2: Hematopoietic Stem Cell Transplantation vs Gene Therapy: how choosing the right treatment for hemoglobinopathies and immune deficiencies
Session Chairs: Dr. Ayman Saleh and Dr. Mehdi Adeli |
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| Objectives:
· Learn about the results of standard treatments for hemoglobinopathies and immune deficiencies. · Discover the role of gene therapy for hemoglobinopathies and immune deficiencies. · Understand how to select patients that can benefit from gene therapy.
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| 11:00 | 11:35 | Keynote Speaker: Dr. Matthew Porteus
Stanford University, USA |
Advancing Genome Editing of Hematopoietic Stem Cells to Engineer Red Blood Cells |
| 11:35 | 12:00 | Dr. Rawad Rihani
King Hussein Cancer Center, Jordan |
Risk adopted approach for allogeneic hematopoietic stem cell transplantation for children with thalassemia major: KHCC experience
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| 12:00 | 12:25 | Dr. Alessia Cavazza
University College London, UK |
Hematopoietic stem cell gene editing for the treatment of Primary Immunodeficiency Diseases.
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| 12:25 | 12:50 | Dr. Davila Saldana Blachy
Children’s National Hospital, USA |
Bone Marrow Transplant for Primary Immunodeficiencies |
| Rapid talks – selected from abstracts
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| 12:50 | 13:00 | Speaker 1 – 3; 9 minutes each
Sarah A. Albasha Mohammed Al-Mana College, Saudi Arabia |
Investigating the DNA methylation profile of childhood solid tumors to identify a novel diagnostic panel |
| 13:00 | 13:10 | Dr. Julie V. Decock Qatar Biomedical Research Institute, Qatar (Oral) |
Computational identification of an immune-related 3-lncRNA signature with prognostic connotation in a multi-cancer setting. |
| 13:10 | 13:20 | Dr. Geethanjali Devadoss Gandhi
Sidra Medicine, Qatar |
The genetic burden of familial hypercholesterolemia in the Qatari population |
| 13:20 | 14:20 | Lunch | |
| Session 3 – Pediatric Cancer Immunotherapy: an evolving field of Precision Medicine (SOCIETY FOR IMMUNOTHERAPY OF CANCER – SITC)
Session Chairs: Dr. Cristina Maccalli and Dr. Davide Bedognetti |
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| Objectives:
· Learn about the most novel applications of immunotherapy in pediatric cancer. · Be acquainted with the recent developments of immunotherapy in pediatric solid cancer. · Understand how targeted treatments can enhance weaponry against pediatric cancer.
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| 14:20 | 14:55 | Keynote Speaker: Dr. Marco Ruella
Hospital of the University of Pennsylvania, USA |
Resistance mechanisms to CART immunotherapy in lymphoid malignancies |
| 14:55 | 15:20 | Dr. Yvonne Chen
University of California Los Angeles, USA |
Engineering Next-Generation CAR-t Cell Therapy for Cancer |
| 15:20 | 15:45 | Dr. Rimas Orentas
Seattle Children’s Hospital, USA |
Moving from Hematologic Malignancy to Solid Tumors: Pathways to Effective Immunotherapy for Pediatric Solid Tumors. |
| 15:45 | 16:10 | Dr. Slaney Clare
University of Melbourne, Australia |
Epigenetic modification of chimeric receptor antigen T cells for treating pancreatic cancers |
| 16:10 | 16:40 | Break | |
| 16:40 | 17:05 | Dr. Hadi Mohamad Abu Rasheed,
Qatar Cancer Society, Qatar |
The role of cancer civil organizations in general and the Qatar cancer society in particular in supporting the precision medicine efforts in Pediatric Cancer Immunotherapy |
| 17:05 | 17:30 | Dr. Franco Marincola
Kite Pharma, USA |
Determinants of CAR-T response and next-generation approaches in LBCL |
| 17:30 | 17:55 | Dr. Eric Bouffet
Sickkids Hospital, Canada |
Targeted therapies in pediatric brain tumors
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| 17:55 | 18:20 | Dr. Christian Capitini
University of Wisconsin-Madison, USA |
Development of NK cell and CAR T cell-based strategies for targeting GD2+ pediatric solid tumors. |
| 18:20 | 18:30 | Closing Remarks | |
| 18:30 | Day Closing | ||
| Day 3: Sunday 25th September 2022
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| TECHNOLOGIES AND EXPERIMENTAL APPROACHES ADVANCING TRANSLATIONAL GENOMICS | |||||
| Rapid talks – selected from abstracts
Moderated by: Dr. Diogo Manoel and Dr. Rafah Mackeh |
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| 8:00 | 8:10 | Speaker 1 – 3; 9 minutes each
Dr. Zeina N. Al-Mahayri College of Medicine and Health Sciences, UAE |
Paving the way for Pharmacogenomics Implementation: lessons learned from a pilot study in the United Arab Emirates | ||
| 8:10 | 8:20 | Dr. Shana Jacob
Sidra Medicine, Qatar |
Lipid metabolism is altered in zebrafish model of MYBPC3 hypertrophic cardiomyopathy | ||
| 8:20 | 8:30 | Dr. Yongsoo Park
QBRI, Qatar |
Mutation of TRPC6, autism candidate gene, induces hyperexcitability of neurons by reducing store-operated calcium entry (SOCE) | ||
| 8:30
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8:50
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Rami Mehio
Head of Global Software and Informatics (Illumina) |
Maximizing Genomic Insights with Whole Genome Sequencing | ||
| Session 1: Cell, organoid and animal models in translational genomics
Session Chairs: Dr. Matteo Avella and Dr. Nady Al Hajj |
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| Objectives:
· Understand the value of using cells, organoids and animals as disease models in biomedical research · Learn about in-vitro and in-vivo experimental approaches used to better understand human genetic disorders · Learn about how patient-derived cells and organoids are advancing precision medicine efforts
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| 8:50 | 9:15 | Opening Keynote: Dr. Bruno Reversade
A*STAR, Singapore |
Leveraging the power of Mendelian genetics to foster innovation for common unmet medical needs | ||
| 9:15 | 9:40 | Dr. Essam Abdelalim
QBRI, Qatar |
Induced pluripotent stem cells as a platform for precision medicine in diabetes | ||
| 9:40 | 10:05 | Dr. Eduardo Zimmer
UFRGS, Brazil |
Imaging Brain Glucose Metabolism | ||
| 10:05 | 10:30 | Dr. Nathalie Jurisch-Yaksi NTNU, Trondheim, Norway |
Mechanisms underlying seizure generation, lessons learnt from the zebrafish | ||
| 10:30 | 10:50 | Break | |||
| 10:50 | 11:25 | Keynote Speaker: Dr. Ana Domingos
Oxford University, UK |
Neuroimmunometabolism.
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| 11:25 | 11:50 | Dr. Xiling Shen
Terasaki Institute, USA |
Patient-Derived Micro-Organospheres Enable Precision Oncology
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| 11:50 | 12:15 | Dr. Michael Wells
UCLA, USA |
Exploration of human genetic and phenotypic diversity through cell villages | ||
| 12:15 | 12:40 | Dr. Franca Ronchese
Malaghan Institute of Medical Research, New Zealand |
Transcriptomic analysis of skin dendritic cell populations provides new insight into their role in allergy development | ||
| 12:40 | 13:05 | Dr. Marcelo Dietrich
Yale University, USA |
Transitions from early life to adulthood that promote health
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| 13:05 | 14:30 | Break | |||
| Pre-recorded workshop on the Chan Zuckerberg Initiative (CZI) funding opportunities. Norbert Tavares, CZI, USA | |||||
| Session 2: Big data and new technologies in precision medicine
Session Chairs: Dr. Nicholas van Panhuys and Dr. Layla Kamareddine |
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| Objectives:
· Understand how large-scale data resources and novel technologies are driving precision medicine · Learn about strategies used to improve disease risk prediction, diagnostics, pathophysiology, and improved treatment strategies · Learn about the latest outcomes in the field and future directions and challenges
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| 14:30 | 14:55 | Afternoon Keynote Speaker: Dr. Eleftheria Zeggini
Helmholtz Munich, Germany |
Translational genomics of complex traits
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| 14:55 | 15:20 | Dr. Pedro Beltrao
ETH, Switzerland |
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| 15:20 | 15:45 | Dr. Saquib A Lakhani
Yale University, USA |
Tackling rare diseases: The Yale Pediatric Genomics Discovery Program
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| 15:45 | 16:10 | Dr. Daniela Robles-Espinoza
UNAM, Mexico |
Genomic profiling of acral melanoma in Latin American patients
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| 16:10 | 16:30 | Break | |||
| 16:30 | 16:55 | Dr. Dorret Boomsma
Vrije Universiteit Amsterdam, The Netherlands |
Next generation Twin Studies |
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| 16:55 | 17:20 | Dr. Albino Oliveira Maia
Champalimaud Foundation, Portugal |
The time for interventional psychiatry
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| 17 :20 | 17 :55 | Closing Keynote Speaker: Giles Yeo, Cambridge University, UK | The brain control of food intake: Can an old dog teach us new tricks | ||
| Day close | |||||
| Day 4: Monday 26th September 2022 | |||
| Topic: LARGE SCALE GENOMES AND PRECISION MEDICINE INITIATIVES IN QATAR AND THE MENA REGION | |||
| Session 1: Precision Medicine in Qatar
Session Chairs: Dr. Khalid Fakhro and Dr. Hamdi Mbarek |
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| Objectives:
· Illustrates the use of the Qatar Genome Project (QGP) in driving precision medicine research · Appreciate the importance of population diversity genomics to reach outcomes in the local and global context · Learn about the latest success stories from landmark studies using QGP data
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| 8:00 | 8:15 | Dr. Khalid Fakhro
Sidra Medicine, Qatar |
TBD |
| 8:15 | 8:30 | Dr. Said Ismail
QGP, Qatar |
Qatar Genome, from basic research to clinical implementation
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| 8:30 | 8:55 | Dr. Younes Mokrab
Sidra Medicine, Qatar |
Genomics reloaded: The missed pieces from Arab and Middle Eastern genomes
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| 8:55 | 9:20 | Dr. Omar Albagha
HBKU, Qatar |
Identification of genetic loci associated with serum levels of thyroid hormones in the Qatari population
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| 9:20 | 9:45 | Dr. Puthen Veettil Jithesh
HBKU, Qatar |
Actionable pharmacogenomic landscape of the Qatari population
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| 9:45 | 10:10 | Dr. Davide Bedognetti
Sidra Medicine, Qatar |
Functional genomics pipelines to dissect mechanisms of cancer immune responsiveness |
| 10:10 | 10:30 | Dr. Khalid Hussain
Sidra Medicine, Qatar |
Precision Medicine for Monogenic Obesity at Sidra Medicine |
| 10:30 | 10:50 | Break | |
| Session 2: Precision Medicine in the Middle East
Session Chairs: Dr. Bernice Lo and Dr. Essam M. Abdelalim |
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| Objectives:
· Understand how large-scale genome sequencing efforts are changing medicine · Learn how molecular diagnostics and disease subtyping improves the quality of patient care · Learn about Precision Medicine efforts being conducted in the Middle Eastern region
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| 10:50 | 11:25 | Morning Keynote Speaker:
Dr. Youssef Idaghdour NYU Abu Dhabi |
Integrative functional genomic analysis of host immune response to infection
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| 11:25 | 11:50 | Dr. Can Alkan
Bilkent University, Turkey |
Algorithms to characterize genomic structural variation using high throughput sequencing technologies |
| 11:50 | 12:15 | Dr. Fatma Al Jasmi
UAE University, UAE |
Precision Medicine in Rare Diseases |
| 12:15 | 12:40 | Dr. Nathalie K. Zgheib
American University of Beirut, Lebanon
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Precision medicine in Low- and middle-income countries: data from Lebanon |
| 12:40 | 13:05 | Dr. Batu Erman
Boğaziçi Üniversitesi, Turkey |
Modeling Rare Diseases: Novel Targets of the LRBA Protein |
| 13:05 | 14:30 | Break | |
| Pre-recorded workshop on the Chan Zuckerberg Initiative (CZI) funding opportunities. Nobert Tavares, CZI, USA | |||
| 14:30 | 14:55 | Keynote Speaker: Dr. Darren Logan, Mars Petcare Science Institutie, UK | Precision healthcare in companion animals
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| Session 3: Sidra Precision Medicine Initiative
Session Chairs: Dr. Luis Saraiva and Dr. Annalisa Terranegra |
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| Objectives:
· Learn about the utility of genetics and functional genomics approaches in the field of rare pediatric disorders · Learn how to expand and advance patient outcomes by conducting the execution of precision medicine in clinical practice · Learn about the latest success stories from the Precision Medicine Initiative at Sidra Medicine · |
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| 14:55 | 15:20 | Dr. Diogo Manoel/ Dr. Luis Saraiva + Dr. Abubakr Imam
Sidra Medicine, Qatar
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Deconstructing the genetics of kidney disease with functional genomics
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| 15:20 | 15:45 | Dr. Bernice Lo + Dr. Amel Hassan
Sidra Medicine, Qatar |
The complexity of genetic diagnosis in highly consanguineous families: A case study from primary immune deficiency |
| 15:45 | 16:10 | Dr. Nicholas van Panhuys
Sidra Medicine, Qatar |
Influences of the Gut Microbiome on the Development of Food Allergies |
| 16:10 | 16:30 | Break | |
| 16:30 | 16:55 | Dr. Wouter Hendricx & Dr. William Mifsud
Sidra Medicine, Qatar |
The precision oncology platform for pediatric solid tumors at Sidra Medicine
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| 16:55 | 17:20 | Dr. Souhaila Al Khodor & Dr. Ibrahim Ibrahim
Sidra Medicine, Qatar |
Gestational Diabetes and the Journey towards Precision Medicine |
| 17:20 | 17:55 | Closing Keynote Speaker: Dr. Ali Gharavi
Columbia University, USA |
Using Genetics to Understand Kidney Disease Pathogenesis and Deliver Personalized Care |
| 17:55 | Poster Awards & conference closing | ||