Zebrafish Functional Genomics Core
Sidra Medicine’s Zebrafish Functional Genomics Core provides an advanced vivo platform to support functional genomics validations, disease modeling, and translational research. Zebrafish are a powerful vertebrate model, with high genetic homology to humans, including shared genes associated with human disease, enabling biologically relevant investigation of genetic variation and disease mechanisms.
The core enables the study of gene function and phenotype at the cellular, tissue, organ, and whole-organism levels, supporting rapid functional validation of genetic findings. Working closely with researchers and clinicians, the facility supports gene discovery, interpretation of patient-specific genetic variants, disease mechanism elucidation, and evaluation of therapeutic strategies, with relevance to pediatric and rare diseases.
Fully automated aquaculture system supporting wild-type and transgenic reporters for zebrafish lines under controlled conditions.
Genetic modification of one-cell stage embryos using CRISPR/Cas9, morpholino, and human gene expression technologies to investigate gene function and generate disease models.
Development and analysis of zebrafish models across multiple disease areas, including neurological, cardiovascular, metabolic, hepatic, skeletal, and congenital disorders.
High-resolution brightfield and fluorescence imaging to assess development, gene expression, and morphological outcomes.
Automated high-throughput systems for behavioral tracking, locomotor analysis, and phenotypic rescue experiments to evaluate functional consequences of genetic variation.
Tissue sectioning, H&E staining, and immunohistochemistry for detailed pathological assessment.
In vivo screens, assays to assess therapeutic response and biological impact.
Functional validation of genetic findings related to Qatar Genome Program to support precision medicine and human health–focused research.
Collaboration from project conception through data interpretation, supporting grant applications and publications.
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