Nico Marr, PhD

Principal Investigator – Assistant Level Systems Immunology and Immune Deficiency Laboratory

Email: nmarr (@)

SELECTED PUBLICATIONS(equal contributions, *corresponding):

  • Khourieh J, Rao G, Habib T, Avery DT, Lefèvre-Utile A, Chandesris MO, Belkadi A, Chrabieh M, Alwaseem H, Grandin V, Sarrot-Reynauld F, Sénéchal A, Lortholary O, Kong XF, Boisson-Dupuis S, Picard C, Puel A, Béziat V, Zhang Q, Abel L, Molina H, Marr N, Tangye SG, Casanova JL, Boisson B. "A deep intronic splice mutation of STAT3 underlies hyper IgE syndrome by negative dominance". Proc Natl Acad SciUSA (2019) 116(33):16463-16472.
  • Hernandez N, Melki I, Jing H, Habib T, Huang SSY, Danielson J, Kula T, Drutman S, Belkaya S, Rattina V, Lorenzo-Diaz L, Boulai A, Rose Y, Kitabayashi N, Rodero MP, Dumaine C, Blanche S, Lebras MN, Leung MC, Mathew LS, Boisson B, Zhang SY, Boisson-Dupuis S, Giliani S, Chaussabel D, Notarangelo LD, Elledge SJ, Ciancanelli MJ, Abel L, Zhang Q, Marr N, Crow YJ, Su HC, Casanova JL. "Life-threatening influenza pneumonitis in a child with inherited IRF9 deficiency." J Exp Med (2018) 215(10):2567-2585.
  • Guérin A, Kerner G, Marr N, Markle JG, Fenollar F, Wong N, Boughorbel S, Avery DT, Ma CS, Bougarn S, Bouaziz M, Béziat V, Della Mina E, Oleaga-Quintas C, Lazarov T, Worley L, Nguyen T, Patin E, Deswarte C, Martinez-Barricarte R, Boucherit S, Ayral X, Edouard S, Boisson-Dupuis S, Rattina V, Bigio B, Vogt G, Geissmann F, Quintana-Murci L, Chaussabel D, Tangye SG, Raoult D, Abel L, Bustamante J, Casanova JL. "IRF4 haploinsufficiency in a family with Whipple's disease." Elife (2018) 7. pii: e32340.
  • Claydon J, Sur A, Callejas A, Ladd M, Kwan E, Taylor R, Turvey SE, Solimano A, Lavoie PM, Marr N*. "Respiratory syncytial virus-neutralizing serum antibody titers in infants following palivizumab prophylaxis with an abbreviated dosing regimen."PLoS One (2017) 12(4):e0176152.
  • Della Mina E, Borghesi A, Zhou H*, Bougarn S*, Boughorbel S*, Israel L, Meloni I, Chrabieh M, Ling Y, Itan Y, Renieri A, Mazzucchelli I, Basso S, Pavone P, Falsaperla R, Ciccone R, Cerbo RM, Stronati M, Picard C, Zuffardi O, Abel L, Chaussabel D, Marr N, Li X, Casanova JL, Puel A. "Inherited human IRAK-1 deficiency selectively impairs TLR signaling in fibroblasts." Proc Natl Acad Sci USA (2017) 114(4):E514-E523.
  • Lavoie PM, Solimano A, Taylor R, Kwan E, Claydon J, Turvey SE, Marr N*. "Outcomes of Respiratory Syncytial Virus Immunoprophylaxis in Infants Using an Abbreviated Dosing Regimen of Palivizumab." JAMA Pediatr(2016) 170(2):174-6.
  • Marr N, Wang TI, Kam SH, Hu YS, Sharma AA, Lam A, Markowski J, Solimano A, Lavoie PM, Turvey SE. "Attenuation of respiratory syncytial virus-induced and RIG-I-dependent type I IFN responses in human neonates and very young children." J Immunol (2014) 192(3):948-57.
  • Sharma AA, Jen R, Brant R, Ladd M, Huang Q, Skoll A, Senger C, Turvey SE, Marr N, Lavoie PM. "Hierarchical maturation of innate immune defences in very preterm neonates." Neonatology (2014) 106(1):1-9.
  • Marr N, Turvey SE, Grandvaux N. "Pathogen recognition receptor crosstalk in respiratory syncytial virus sensing: a host and cell type perspective." Trends Microbiol (2013) 21(11):568-74.
  • Marr N, Turvey SE. "Role of human TLR4 in respiratory syncytial virus-induced NF-κB activation, viral entry and replication." Innate Immun(2012) 18(6):856-65.