Jean-Charles Grivel, PhD

Director - Deep Phenotyping Core Principal Investigator – Associate Level Deep Phenotyping Core

Email: jgrivel (@)

Selected publications (co-first, *corresponding):

  • Maacha S, Bhat AA, Jimenez L, Raza A, Haris M, Uddin S, and Grivel JC*. Extracellular vesicles-mediated intercellular communication: roles in the tumor microenvironment and anti-cancer drug resistance. Molecular cancer. 2019;18(1):55.
  • Zicari S, Arakelyan A, Fitzgerald W, Zaitseva E, Chernomordik LV, Margolis L, and Grivel JC*. Evaluation of the maturation of individual Dengue virions with flow virometry. Virology. 2016;488:20-7.
  • Fitzgerald W, and Grivel JC*. A universal nanoparticle cell secretion capture assay. Cytometry A. 2013;83(2):205-11.
  • Arakelyan A, Fitzgerald W, Margolis L, and Grivel JC*. Nanoparticle-based flow virometry for the analysis of individual virions. The Journal of clinical investigation. 2013;123(9):3716-27.
  • Grivel JC, and Margolis L. Use of human tissue explants to study human infectious agents. Nature protocols. 2009;4(2):256-69.
  • Biancotto A, Iglehart SJ, Vanpouille C, Condack CE, Lisco A, Ruecker E, Hirsch I, Margolis L, and Grivel JC. HIV-1 induced activation of CD4+ T cells creates new targets for HIV-1 infection in human lymphoid tissue ex vivo. Blood. 2008;111(2):699-704.
  • Münch J, Rücker E, Ständker L, Adermann K, Goffinet C, Schindler M, WildumS, Chinnadurai R, Rajan D, Specht A, Giménez-Gallego G, Sánchez PC, Fowler DM,Koulov A, Kelly JW, Mothes W, Grivel JC, Margolis L, Keppler OT, Forssmann WG,Kirchhoff F. Semen-derived amyloid fibrils drastically enhance HIV infection. Cell. 2007;131(6):1059-71.
  • Grivel JC, Ito Y, Faga G, Santoro F, Shaheen F, Malnati MS, et al. Suppression of CCR5- but not CXCR4-tropic HIV-1 in lymphoid tissue by human herpesvirus 6. Nat Med. 2001;7(11):1232-5.
  • Penn ML, Grivel JC, Schramm B, Goldsmith MA, and Margolis L. CXCR4 utilization is sufficient to trigger CD4+ T cell depletion in HIV-1-infected human lymphoid tissue. Proc Natl Acad Sci U S A. 1999;96(2):663-8.
  • Grivel JC, and Margolis LB. CCR5- and CXCR4-tropic HIV-1 are equally cytopathic for their T-cell targets in human lymphoid tissue. Nat Med. 1999;5(3):344-6.