Dr Chaussabel obtained his PhD from the University of Brussels in 1999. As a trained immunologist, he acquired expertise in the genomics and bioinformatics fields, with the use of whole genome transcriptional profiling tools as a postdoctoral fellow at the NIAID/NIH for the study of host-pathogen interactions. Prior to joining Sidra, Dr. Chaussabel developed a genomics and bioinformatics program at the Baylor Institute for Immunology Research in Dallas TX (2004-2010). He served as head of the Systems Immunology Division at the Benaroya research institute in Seattle WA (2010-2014) where he led studies investigating “genomic reprograming” that occurs in the blood of patients with infectious and autoimmune diseases as well as in response to vaccination.
Our group employs system-scale profiling approaches to investigate immunological mechanisms involved in health maintenance and pathogenesis. Specifically, profiling of blood transcripts at high temporal frequency is employed for biomarker discovery work. One study focuses on pre-symptomatic detection of adverse events in pregnancy (B. Kabeer). A second study focuses on early diagnosis of post-operative sepsis in infants (M. Garand). In addition to conducting clinical studies our group develops hands-on educational programs using public omics data as source of training material. This activity extends to investigations of candidate genes in the laboratory (gene and expression profiling, functional studies employing CRISPR/Cas9).
Basirudeen Kabeer, PhDStaff ScientistEmail: bkabeer (@) sidra.orgMathieu Garand, PhDStaff ScientistEmail: mgarand (@) sidra.orgMohammed Toufiq, BScResearch SpecialistEmail: mtoufiq (@) sidra.orgMohamed Alfaki, BScResearch SpecialistEmail: malfaki (@) sidra.org
SELECTED PUBLICATIONS(†equal contribution, *corresponding):
- Huang SSY, Al Ali F, Boughorbel S, Toufiq M, Chaussabel D, Garand M. A curated collection of transcriptome datasets to investigate the molecular mechanisms of immunoglobulin E-mediated atopic diseases. Database (2019) 2019: baz066.
- Brummaier T, Syed Ahamed Kabeer B, Lindow S, Konje JC, Pukrittayaamee S, Utzinger J, Toufiq M, Antoniou A, Marr AK, Suriyakan S, Kino T, Al Khodor S, Terranegra A, Nosten F, Paris DH, McGready R, Chaussabel D. A prospective cohort for the investigation of alteration in temporal transcriptional and microbiome trajectories preceding preterm birth: a study protocol. BMJ Open (2019) 9(1):e023417.
- Dunning J, Blankley S, Hoang LT, Cox M, Graham CM, James PL, Bloom CI, Chaussabel D, Banchereau J, Brett SJ, Moffatt MF, O'Garra A, Openshaw PJM; MOSAIC Investigators. Progression of whole-blood transcriptional signatures from interferon-induced to neutrophil-associated patterns in severe influenza. Nat Immunol (2018) 19(6):625-635.
- Chaussabel D, Rinchai D. Using 'collective omics data' for biomedical research training. Immunology. (2018) 155(1):18-23.
- Jaggi P, Mejias A, Xu Z, Yin H, Moore-Clingenpeel M, Smith B, Burns JC, Tremoulet AH, Jordan-Villegas A, Chaussabel D, Texter K, Pascual V, Ramilo O. Whole blood transcriptional profiles as a prognostic tool in complete and incomplete Kawasaki Disease. PLoS One (2018) 13(5):e0197858.
- Israel L, Wang Y, Bulek K, Della Mina E, Zhang Z, Pedergnana V, Chrabieh M, Lemmens NA, Sancho-Shimizu V, Descatoire M, Lasseau T, Israelsson E, Lorenzo L, Yun L, Belkadi A, Moran A, Weisman LE, Vandenesch F, Batteux F, Weller S, Levin M, Herberg J, Abhyankar A, Prando C, Itan Y, van Wamel WJB, Picard C, Abel L, Chaussabel D, Li X, Beutler B, Arkwright PD, Casanova JL, Puel A. Human Adaptive Immunity Rescues an Inborn Error of Innate Immunity. Cell (2017) 23;168(5):789-800.e10.
- Rinchai D, Anguiano E, Nguyen P, Chaussabel D. Finger stick blood collection for gene expression profiling and storage of tempus blood RNA tubes. Version 2. F1000Res (2016, revised 2017) 5:1385.
- Rinchai D, Presnell S, Vidal M, Dutta S, Chauhan V, Cavanagh D, Moncunill G, Dobaño C, Chaussabel D. Blood Interferon Signatures Putatively Link Lack of Protection Conferred by the RTS,S Recombinant Malaria Vaccine to an Antigen-specific IgE Response. Version 2. F1000Res (2015) 4:919.
- Alsina L, Israelsson E, Altman MC, Dang KK, Ghandil P, Israel L, von Bernuth H, Baldwin N, Qin H, Jin Z, Banchereau R, Anguiano E, Ionan A, Abel L, Puel A, Picard C, Pascual V, Casanova JL, Chaussabel D. A narrow repertoire of transcriptional modules responsive to pyogenic bacteria is impaired in patients carrying loss-of-function mutations in MYD88 or IRAK4. Nat Immunol (2014) 15(12):1134-42.
- Obermoser G, Presnell S, Domico K, Xu H, Wang Y, Anguiano E, Thompson-Snipes L, Ranganathan R, Zeitner B, Bjork A, Anderson D, Speake C, Ruchaud E, Skinner J, Alsina L, Sharma M, Dutartre H, Cepika A, Israelsson E, Nguyen P, Nguyen QA, Harrod AC, Zurawski SM, Pascual V, Ueno H, Nepom GT, Quinn C, Blankenship D, Palucka K, Banchereau J, Chaussabel D. Systems scale interactive exploration reveals quantitative and qualitative differences in response to influenza and pneumococcal vaccines. Immunity (2013) 38(4):831-44.