Dr. Ismail Chouchane received her MD degree from the Faculty of Medicine of Sousse, Tunisia. Following four-year residency training in Dermatology & Venereology at several teaching hospitals in Tunisia and France, she obtained her Medical Specialty Degree in Dermatology & Venereology. She then joined the US National Institute of Heath for a fellowship in biomedical research during which she worked on several areas of Dermatology Research. With her more than 24-year clinical experience, she held the positions of Consultant and Senior Consultant in Dermatology and Venereology at several medical institutions.Throughout her carrier, besides her work as clinician, Dr. Ismail Chouchane held research positions among which a position at Weill Cornell Medicine-Qatar in 2012.In 2014 she joined Sidra Medicine as principal investigator where she built the first Dermatology Research group in Qatar
The main research interest of the Laboratory of Dermatology Research led by Dr. Ismail Chouchane is the Genetics and Physiopathology of Skin Diseases and the Rare Genetic Skin Disorders.Using the most advanced technologies, her research is designed to understand the causes and molecular pathways underlying skin conditions, and to identify potential markers that may serve for drug discovery, treatment and prevention of these diseases.Through an integrated epidemiologic, functional genomic, epigenomic and transcriptomic approaches, her work is aimed to generate a prioritized panel of epidemiologic risk factors, genes, proteins and molecular pathways associated with skin diseases and to assess their implications in preventive and predictive medicine.
Seetharama Konduru Sastry, PhDStaff ScientistEmail: skonduru (@) sidra.orgThasni Karedath Abdul Azis, PhDPostdoctoral FellowEmail: tkaredathabdulazis (@) sidra.orgWafa Naim Abdelgalil Ibrahim, MDResearch SpecialistEmail: wibrahim (@) sidra.org
SELECTED PUBLICATIONS(†equal contribution, *corresponding):
- Umar M, Sastry KS, Chouchane I. A.Role of Vitamin D Beyond the Skeletal Function: A Review of the Molecular and Clinical Studies.Int J Mol Sci (2018) 19 (6), 1618.
- Umar M, Sastry KS, Al Ali F, Al-Khulaifi M, Wang E, Chouchane IA. Vitamin D and the Pathophysiology of Inflammatory Skin Diseases. Skin Pharmacol Physiol (2018) 6;31(2):74-86.
- Sastry KS, Chouchane IA, Wang E, Kulik G, Marincola FM, Chouchane L. Cytoprotective effect of neuropeptides on cancer stem cells: vasoactive intestinal peptide-induced antiapoptotic signaling. Cell Death Dis (2017) 8(6):e2844.
- Megabane A, Al-Ali R, Choucair N, Lek M, Wang E, Ladjimi M, Rose CM, Hobeika R, Macary Y, Temanni R, Jitesh PV, Chouchane A, Sastry KS, Thomas R, Tomei S, Liu W, Marincola F, Mac Arthur D, Chouchane L.Temple- Baraitser Syndrome and Ziemmermann-Laband Syndrome: One clinical Entity? BMC Med Genet (2016) 10:17(1):42.
- Sastry KS, Al-Muftah MA, Li P, Al-Kowari MK, Wang E, Ismail Chouchane A, Kizhakayil D, Kulik G, Marincola FM, Haoudi A, Chouchane L. Targeting proapoptotic protein BAD inhibits survival and self-renewal of cancer stem cells. Cell Death Differ (2014) 12:1936-49.
- L. Chouchane, I. Sfar, R. Bousaffara, A. El Kamel, M.T. Sfar, and A. Ismaïl. A repeat polymorphism in interleukin-4 gene is highly associated with specific clinical phenotypes of asthma. Int Arch Allergy Immunol. (1999)120: 50-55.
- A. Ismaïl, Bousaffara R, Kaziz J, Zili J, el Kamel A, Tahar Sfar M, Remadi S, Chouchane L. Polymorphism in transporter antigen peptides gene (TAP1) associated with atopy in Tunisians. J Allergy Clin Immunol (1997)99: 216-23.
- S. Remadi, W. McGee, J.F.Egger, and A. Ismaïl. Ovarian metastatic melanoma. Arch Anat Cytol Pathol(1997) 45:43-46.
- S. Remadi, W. Mc Gee, I Doussis-Anagnostopoulou, S. Diebold Berger, and A. Ismaïl. Papillary-cystic tumor of the pancreas. Diagn Cytopathol (1996) 15:398-402.