PROGRAM SCHEDULE
Precision Medicine and Functional Genomics 2020
Virtual Meeting (PMFG 2020)

Over the last few years, the field of genomic medicine has moved very rapidly from sequencing the genomes of thousands of individuals to clinical applications in diagnosis, therapy and prevention. As part of its National Vision 2030, Qatar is committed to building a knowledge-based economy in the biomedical and health sciences. Sidra aims to become a leading model for Precision Medicine in the region, by combining research, education and clinical practice to successfully tackle conditions affecting women and children in Qatar. In line with this vision, FG 2020 will bring together scientists, academics, healthcare professionals, policy makers and community members to explore the latest developments and innovations in genomics research and how they translate into precision medicine solutions across diverse global settings.

The FG 2020 virtual meeting will deliver live and on-demand programming, selected abstract sessions as well as special sessions on COVID-19 and the biotech/pharma industry’s role in precision medicine.

Target Audience

Researchers
Physicians
Students
Nurses
Pharmacists
Allied Health
Public Health
Public Policy
Biotech Industry

Target Audience

List examples of precision medicine solutions or treatments currently in practice
Provide an overview of lessons and discoveries from large-scale genomics projects, e.g. Qatar Genome Program
Explain how advanced technologies have helped to rapidly study COVID-19
Describe briefly how multi-omics studies have facilitated personalized medicine

DAY 1: SATURDAY 5TH DECEMBER 2020 “EXPANDING THE PRECISION MEDICINE POTENTIAL”
14:00 - 14:05	Dr. Damien Chaussabel Director - Immunology Program Sidra Medicine - State of Qatar	Opening remarks
14:05 - 14:10	Dr. Bernice Lo Investigator - Human Genetics Sidra Medicine - State of Qatar	Opening remarks

SESSION 1: FROM HUNDREDS TO MILLIONS OF GENOMES: LARGE-SCALE DISCOVERIES DRIVING PRECISION MEDICINE Objectives: 1. Present the latest advances from landmark global projects 2. Appreciate the impact of large-scale genomics in serving precision medicine 3. Highlight Qatar Genome Program’s initiatives and outcomes in the global context
14:10 - 14:15	Dr. Donald Love Division Chief, Pathology Genetics Sidra Medicine, State of Qatar	Introduction by Session Chair
14:15 - 14:30	Dr. Hamdi Mbarek Qatar Genome Program, Qatar	“The Qatar Genome Project: design, project goals and first results”
14:35 - 14:55	Professor Omar AlBagha College of Health and Life Sciences Hamad Bin Khalifa University, State of Qatar	“The Performance of European-derived Polygenic Scores for Health-Related Traits in the Qatari Population”
14:55 - 15:00	Break
15:05 - 15:25	Professor Stephen Scherer, Ph.D Director, McLaughlin Centre and The Centre for Applied Genomics, The Hospital for Sick Children, University of Toronto, Canada	“Open Science Genomes from 15,000+ Individuals with Autism and Family Members, Impacting Precision Medicine”
15:30 - 15:50	Dr. Ronald G Crystal, MD Chair, Genetic Medicine Weill Cornell Medicine, New York, USA	“QChip1 - A Genotyping Microarray for Identification of Single Gene Disorders in Qatar”
15:55 - 16:15	Dr. Geoffrey Ginsburg Professor of Medicine, Center for Applied Genomics & Precision Medicine \| MEDx Duke University School of Medicine, NC, USA	“The International 100K+ Cohorts Consortium: Integrating Large-Scale Cohorts to Address Global Scientific Challenges”
16:20 - 16:45	Keynote Speaker: Professor Sir Mark Caulfield Chief Scientist, Genomics England, UK	“100,000 Genomes Project and health transformation”
16:50 - 17:05	Dr. Georges Nemer Professor of Genomics & Precision Medicine Head of the Genomics & Translational Biomedicine Division, College of Health & Life Sciences, Hamad Bin Khalifa University, State of Qatar	“Education in Precision Medicine: Ethics in Sharing Knowledge Across Borders”
17:05 - 17:10	Break

SESSION 2: PRECISION MEDICINE SOLUTIONS FOR MANAGING COVID-19 Objectives: 1. Provide examples of current strategies for managing COVID-19 2. Explain how omics approaches have contributed to our understanding of COVID-19 3. Describe an example of a precision medicine approach to managing COVID-19
17:10 - 17:15	Dr. Luis Saraiva Director-Metabolism and Diabetes Program, Sidra Medicine - State of Qatar	Introduction by Session Chair
17:15 - 17:30	Dr. Serhiy Souchelnytskyi, Ph.D Professor, College of Medicine Qatar University, State of Qatar	“Systems biology insights into COVID-19 and clinical applications”
17:35 - 17:50	Professor Stuart Tangye, Ph.D Leader, Immunity & Inflammation Theme Head, Immunology & Immunodeficiency Lab, Garvan Institute of Medicine Research, Australia	“COVID19 – lessons learned from inborn errors of immunity”
17:55 - 18:10	Dr. Hadi Yassine, PhD Section Head of Research Institutional Biosafety Committee (IBC) Chair Associate Professor of Infectious Diseases Qatar University Biomedical Research Center, Qatar	“A One Health Approach to Address COVID-19 in Qatar”
18:15 - 18:30	Dr. Laith J. Abu-Raddad Professor of Infectious Disease Epidemiology and Director of WHO Collaborating Center for Disease Epidemiology Analytics	“Epidemiological insights from the novel primary data on the Qatar SARS-CoV-2 epidemic”
18:30 - 18:35	Break
18:40 - 18:55	Dr. Micah McClain, MD, PhD Associate Professor of Medicine, Division of Infectious Diseases Center for Applied Genomics and Precision Medicine, Duke University Medical Center, NC, USA	TBC
19:00 - 19:15	Dr. Christopher Mason, Ph.D Associate Professor, Department of Physiology and Biophysics Weill Cornell Medicine, New York, USA	“Shotgun and spatial transcriptome profiling of COVID-19 patients and autopsies”
19:20 - 19:45	Keynote Speaker: Professor Adolfo Garcia-Sastre, PhD Professor of Medicine and Microbiology The Icahn School of Medicine at Mount Sinai in New York City, USA	“Development of COVID-19 vaccines”
19:45 - 19:50	Closing remarks

Day 2: Sunday 6th December 2020
“PRECISION MEDICINE AS IT STANDS TODAY”

SESSION 3: REALIZING THE PROMISE OF PRECISION MEDICINE IN CLINICAL CARE Objectives: 1. Name an advanced technology/treatment available currently 2. Describe an example of how a targeted therapy improved patient outcome 3. Explain how genetic testing can impact clinical treatment
14:00 - 14:05	Dr. Olivier Chez Division Chief - Cardiovascular Surgery, Sidra Medicine – State of Qatar	Introduction by Session Chair
14:05 - 14:20	Professor Jonathan Skinner, MD Paediatric Cardiologist/Electrophysiologist Sydney Children's Hospital Network, Australia	“Genomics and the prevention of sudden death”
14:25 - 14:40	Dr. Amel Hassan, M.D Senior Attending Physician, Sidra Medicine, State of Qatar	“Precision medicine transforming the lives of children with Primary Immunodeficiency (PID)”
14:45 - 15:05	2 short talks from selected abstracts
15:10 - 15:15	Break
15:15 - 15:30	Dr. Richard Gibbs, Ph.D Director, Baylor College Of Medicine Human Genome Sequencing Center, Wofford Cain Professor Of Human And Molecular Genetics, Australia	“High Genetic Testing Yield in an Enriched Adult Cohort”
15:35 - 15:50	Professor Tippi MacKenzie Professor of Surgery, Director of Research, Fetal Treatment Center, Co-Director, UCSF Center for Maternal-Fetal Precision Medicine, USA	“Reinventing Fetal surgery: Molecular therapies for genetic diseases”
15:55 - 16:10	Professor Mariya Moosajee Professor of Molecular Ophthalmology at UCL Institute of Ophthalmology, Hospital for Children, London, UK	“How has the 100,000 Genome Project shaped Genomic Ophthalmology”
16:15 - 16:40	Keynote Speaker: Dr. Stephen Hunger, M.D Chief, Division of Pediatric Oncology Director, Center for Childhood Cancer Research, Children’s Hospital of Philadelphia, USA	“Implementing New Precision Medicine and Immunotherapy Strategies in Pediatric Acute Lymphoblastic Leukemia”
16:40 - 17:00	Workshop break

SESSION 4: LESSONS FROM INDUSTRY & BIOTECHNOLOGY COMPANIES AT THE FRONTLINE OF PRECISION MEDICINE Objectives: 1. Explore strategies for tackling the heterogeneity of diseases 2. Describe the application potential of sequencing to patient care 3. Provide examples of successful translational approaches
17:00 - 17:05	Dr. Cristina Maccalli Principal Investigator Laboratory of Immune and Biological Therapy, Cancer Program, Sidra Medicine - State of Qatar	Introduction by Session Chair
17:05 - 17:20	Dr. Adrian Bot, M.D. Ph.D. Vice President and Global Head, Translational Medicine Kite, a Gilead Company, USA	“Development of CAR T cell products for treatment of B cell malignancies”
17:25 - 17:40	Dr. Ali Mohamed VP CMC, Immatics US, Inc., USA	“Adoptive cell therapy using allogeneic TCR engineered T cells”
17:45 - 18:00	Dr. Khaled Machaca, PhD Professor and Senior Associate Dean for Research, Innovation & Commercialization. Weill Cornell Medicine-Qatar, State of Qatar	“Personalized medicine approaches in Qatar”
18:05 - 18:25	2 short talks from selected abstracts
18:30 - 18:35	Break
18:35 - 18:50	Dr. Dan Crowley CEO and co-founder of RemedyBio, Ireland	“Beyond Genotype-Phenotype: How Functional Biology Will Transform Genomics"
18:55 - 19:10	Dr. Franco Marincola, MD President and Chief Scientific Officer at Refuge Biotechnologies, California, USA	“Contextual regulation of cell function for adoptive cell therapy”
19:15 - 19:40	Keynote Speaker: Dr. Alan Shuldiner Vice President, Regeneron Pharmaceuticals, Inc., New York, USA	“The Regeneron Genetics Center at 1 million exomes: What have we learned”
19:45 - 19:50	Closing remarks

DAY 3: MONDAY 7TH DECEMBER 2020
“THE FUTURE OF FUNCTIONAL GENOMICS & PRECISION MEDICINE”

SESSION 5: FROM COMPLEX DATASETS TO TANGIBLE CLINICAL INSIGHTS Objectives: 1. Describe the potential impact on big data mining on healthcare 2. Provide an overview of data integration approaches aimed at clinical applications 3. Outline processes underlying translation of research findings into clinical applications 4. Show examples illustrating challenges and opportunities for big data in patient care
14:00 - 14:05	Dr. Younes Mokrab Principal Investigator Medical and Population Genomics Lab Sidra Medicine- State of Qatar	Introduction by Session Chair
14:05 - 14:30	Keynote Speaker: Dr. Daniel MacArthur Director of the Centre for Population Genomics Garvan Institute of Medical Research, Sydney, Australia	“Using large-scale genomic databases to interpret the impact of human variation”
14:35 - 14:50	Professor Hilary Martin Group Leader, Medical and Population Genomics, Sanger Institute, United Kingdom	“Illuminating genetic architecture in the Deciphering Developmental Disorders project”
14:55 - 15:15	Dr. Borbala Mifsud Assistance Professor in Genomics & Precision Medicine, Hamad Bin Khalifa University, State of Qatar	“PML-RARA drives context-specific activities in Acute Promyelocytic Leukemia”
15:20 - 15:25	Break
15:25 - 15:40	Professor Lara Mangravite President of Sage Bionetworks, USA	“Open practices that drive translation from data-intensive research”
15:45 - 16:00	Daniel Geschwind, M.D, Ph.D Gordon and Virginia MacDonald Distinguished Professor, Neurology Psychiatry and Human Genetics Senior Associate Dean and Associate Vice Chancellor, Precision Health Director, Institute of Precision Health, UCLA, USA	“Systems biology in neuropsychiatric disorders”
16:05 - 16:20	Dr. Paul Thompson, PhD Directs the ENIGMA Center for Worldwide Medicine, Imaging & Genomics, USA	“ENIGMA & Global Neuroscience: Discovering genomic loci that affect the speed of brain development and aging in worldwide”
16:25 - 16:40	Dr. Pui Kwok, MD, PhD Professor at UCSF and Director of the Institute of Biomedical Sciences at the Academia Sinica, Taiwan	“Full genome analysis for rare genetic disease diagnosis”
16:45 - 17:05	Workshop break

SESSION 6: LARGE SCALE MULTI-OMICS POPULATION STRATIFICATION TO ENABLE PERSONALIZED MEDICINE Objectives: 1. Explain the concept of stratified medicine 2. List examples of approaches / platforms that can be employed for molecular or cellular profiling-based stratification 3. Describe a case in which omics approaches have facilitated precision medicine
17:00 - 17:05	Dr. Jean-Charles Grivel Director- Deep Phenotyping Core, Sidra Medicine- State of Qatar	Introduction by Session Chair
17:05 - 17:20	Dr. Stephen Montgomery Associate Professor of Pathology, Genetics and, by courtesy, Computer Science at Stanford University, USA	“Prediction of genetic risk using multi-omics outlier variants”
17:25 - 17:40	Professor Alban Baruteau Chief of Service, Medico-surgical department of pediatric and congenital cardiology, Nantes University Hospital, France	“Genetic risk of sudden infant death syndrome”
17:45 - 18:00	Dr. Andrea Ballagi VP Sales and Marketing, Olink Proteomics , Sweden	“Protein biomarkers to aid Precision Medicine”
18:05 - 18:25	2 short talks from selected abstracts
18:30 - 18:35	Break
18:35 - 18:50	Professor Dr. Kastern Suhre Director Bioinformatics Core, Weill Cornell Medicine - Qatar	“Aptamer-based proteomics in population studies”
18:55 - 19:10	Dr. C. Thomas Caskey, MD Precision, Corp. Scientific Advisor, Baylor College of Medicine. Prof. Dept of Human and Molecular Genetics and Genome Center, USA	“Precision Medicine is Enhanced with Metabolomics and MRI Whole Body Imaging”
19:15 - 19:40	Keynote Speaker: Dr. Virginia Pascual, MD Ronay Menschel Professor of Pediatrics, Director, Drukier Institute for Children’s Health, Weill Cornell Medicine- New York, USA	“A Personalized Approach to Understand Systemic Lupus Erythematosus Heterogeneity”
19:45 - 19:50	Abstract winner announcement and closing remarks

“This activity was planned by and for the healthcare team, and learners will receive 14.25 hours Qatar Council of Healthcare Practitioner (QCHP) credits for learning and change.”

In support of improving patient care, Sidra Medicine is jointly accredited by the Accreditation Council for Contiuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team. The Scientific Planning Committee has reviewed all disclosed financial relationships of speakers, moderators, facilitators, and/or authors in advance of this CPD activity and has implemented procedures to manage any potential or real conflicts of interest.

PROGRAM SCHEDULE Precision Medicine and Functional Genomics 2020 Virtual Meeting (PMFG 2020)

PROGRAM SCHEDULE
Precision Medicine and Functional Genomics 2020
Virtual Meeting (PMFG 2020)