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Sidra Symposia Series: Advances of Proteomics in Personalized Medicine and Translational Research

As part of Sidra’s mission to improve the standards of health and wellbeing for women and children, we host the Sidra Symposia Series (SSS), which aims to bring healthcare professionals together to discuss topical issues currently affecting the local and regional population.

Previous areas we’ve covered in the Symposia Series include childhood obesity, breastfeeding, fetal malformation, gestational diabetes mellitus, pre-term labor and immunotherapy of cancer (hosted in partnership with the Society for the Immunotherapy of Cancer). The focus of our latest event was on advances of proteomics in personalized medicine and translational research.

The term “proteomics” has two definitions. Traditionally, it refers to the large-scale analysis of gene products in studies involving only proteins. By more recent and broader definition, proteomics are protein studies with analysis that have a genetic readout such as mRNA analysis, genomics, and the yeast two-hybrid analysis. Regardless, the goal of proteomics remains the same: to obtain a more global and integrated view of biology, by studying all the proteins of a cell rather than each one individually.

Dr. Ena Wang, Sidra Division Chief of Translational Medicine, kicked off the symposium by welcoming international speakers who had travelled from institutions all over the world to join us, including the Macquarie University in Australia, University of Southampton in England, University of Lund in Sweden, National Centre for Biological Sciences in India, Cincinnati Children’s Hospital Medical Centre, SomaLogic Inc, George Mason University, and the National Institute of Allergy and Infectious Diseases (all USA). Joining us from a little closer to home, we were also delighted to host speakers from Qatar Biomedical Research Institute and Weill Cornell Medical College in Qatar.

Our first session of the day looked at the technology paradigm change around proteomics, and was moderated by Dr. Hilal Ahmaed Lashuel, executive director of the Qatar Biomedical Research Institute. A recipient of several prestigious awards, including the ERC and Human Science Frontiers young investigator awards, Dr. Lashuel has had over 110 publications and more than 150 invited lectures in his research field, which focuses on understanding the molecular mechanisms of neurodegeneration and developing novel strategies to diagnose and treat neurodegenerative diseases.

Session two focused on proteomic application in personalized medicine and research and was moderated by Gyorgy Marko-Varga, professor and head of the division of clinical protein science and imaging at the University of Lund. Professor Marko-Varga started in 1992 as a lead scientist in a collaboration with the Nobel Prize winner Bengt Samuelsson. He has been in leadership positions in AstraZeneca for more than 20 years as global proteomics head of Clinical Biomarker Platforms and Biological Mass Spectrometry.

Insights were provided by a panel of esteemed experts, including Thomas Fehniger, director of the center of excellence in biological and medical mass spectrometry at the biomedical center of Lund University, who spoke on the microenvironments of disease. Mark Baker, cancer and proteomics researcher and ‎co-founder of the Australasian Proteomics Society, presented on the translation of membrane proteome interactions into novel colorectal cancer targets. Johannes Graumann, assistant professor of biochemistry and director of proteomics at Weill Cornell Medical College, closed the second session by discussing the proteomic characterization of the differentiation pathway, from human embryonic stem cells to mesenchymal stem cells.¬¬¬¬¬

“It has been an honor to welcome leaders in the proteomics field from across the globe to Sidra, and to facilitate fascinating discussions on the discipline. The Sidra Symposia Series has been a great success and we remain committed to and passionate about providing this educational platform for the medical community in Qatar and beyond,” Said Dr. Wang.

Be sure to stay informed on the latest medical issues impacting the Middle East by registering your attendance to our next Sidra Symposia Series, via our events page.

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